Inflammation in Aging and Age-related disease, San Antonio Nathan Shock Aging Center 2011 Conference on Aging, Mayan Ranch, Texas Hill Country, Bandera, TX, USA
نویسندگان
چکیده
The San Antonio Nathan Shock Center Conferences have attracted international speakers and participants since 1995. This annual conference, held in Bandera, Texas, USA, addresses a different topic in the biology of aging each year. The venue's intimate setting, relatively remote location, and common areas are ideal for a small conference (80Á100 participants), where copious informal intellectual interchange supplements that of the formal sessions. The 2011 meeting, part of an annual series sponsored by the Excellence in the Biology of Aging, addressed the causes of age-associated inflammation and its effect on age-associated diseases. It is firmly established that aging is associated with chronic low-grade inflammation. Chronic inflammation has been proposed to be a primary cause of aging, to exacerbate/accelerate age-associated diseases such as Alzheimer's disease, to alter normal immune function and thereby increase susceptibility to infection and cancer, and to be a viable pharmacological target for delayed disease progression and enhanced longevity. Age-associated inflammation is the result of a wide range of factors that include deregulation of senescent cells, environmental exposures, and age-associated illnesses. Thus, age-associated inflammation can be considered as both cause and effect during aging at the cellular and organismal level and is inseparable from almost all aspects of biological aging. The purpose of the 2011 conference was to provide a forum for the presentation and dissemination of recent findings pertaining to age-associated inflammation. To this end, speakers were recruited who are working on exciting new studies that help to clarify the molecular mechanisms underlying age-associated inflammation, and its causal relationship to diabetes, muscle wasting, neurodegenerative diseases, cancer, and infection and immunity, as well as a target for prophylactic intervention. Importantly, in vivo animal models of inflammation during aging were emphasized. Thus, an exciting conference was organized relevant to the understanding of the basis of inflammation during aging, its contribution toward development of age-related diseases, and how anti-inflammatory regimens might confer protection. Abstracts from posters presented at the meeting are presented in this special abstract issue to provide an overview of the breadth and depth of the program. A follow-up issue will publish papers submitted by invited speakers and other participants. Emerging evidence has implicated the gastrointestinal flora in the pathogenesis of insulin resistance by causing chronic, low-grade endotoxemia. The goals of this study were to determine: (1) whether obese non-diabetic and obese diabetic subjects have abnormal endotoxin [lipopolysaccharide (LPS)] concentrations in plasma; (2) whether LPS promotes an inflammatory …
منابع مشابه
Abstracts from the Annual Conference on Aging, Mayan Ranch, Texas Hill Country, Bandera, Texas, USA, 2013
The San Antonio Nathan Shock Center Conferences have attracted international speakers and participants since 1995. This annual conference, held in Bandera, Texas, addresses a different topic in the biology of aging each year. The venue's intimate setting, relatively remote location and common areas are ideal for a small conference (80Á100 participants) where informal intellectual interchange su...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2011